The proteomic analysis of oral bacterial pathogens
Professor Eric Reynolds
03 9341 1547
This project focuses on using using 2D-gel electrophoresis, multidimensional LC and mass spectrometry analyses to identify outer membrane associated proteins and antigens of Porphyromonas gingivalis, Treponema denticola and Tanerella forsythia, the bacteria associated with periodontitis. We are also investigating the effect of environmental conditions including growth as a biofilm and iron availability on bacterial protein expression. This work will enable us not only to identify novel antigenic proteins that may be used for the development of vaccines against these bacteria but will also help us to understand the role of a variety of bacterial proteins in their virulence and physiology.
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