Dr. Peiyan Shen
Tel: +61 3 9341 1562
QUALIFICATIONS AND POSITION
- Senior Research Fellow, Oral Health CRC, Melbourne Dental School, The University of Melbourne
- B.Med. (Shandong Medical University)
- M.Sc. (Shandong Medical University)
- Ph.D. (University of Melbourne)
- Senior Research Fellow, Oral Health Science, Melbourne Dental School, University of Melbourne.
- Research Fellow, Oral Health Science, Melbourne Dental School, University of Melbourne.
- Research Fellow, Department of Genetics, University of Melbourne.
Nanobiotechnology – Clinical Studies of Biomineralising Casein Phosphopeptides (CPP)
Casein phosphopeptides (CPP) containing the cluster sequence -Ser(P)-Ser(P)-Ser(P)-Glu-Glu- have a remarkable ability to stabilize amorphous calcium phosphate (ACP) in metastable solution. Through the multiple phosphoseryl residues, the CPP bind to forming clusters of ACP preventing their growth to the critical size required for nucleation and phase transformation. The CPP can be obtained from a tryptic digest of the major bovine milk protein casein by titrating the digest with CaCl2 and Na2HPO4 at pH 9.0 generate ACP and removal of the CPP-ACP complexes formed by microfiltration. The CPP-ACP has been shown to reduce caries activity in specific-pathogen-free rats orally infected with Streptococcus sobrinus. In a human in situ enamel demineralization study a 1% w/v CPP-ACP solution used twice daily by 12 subjects produced a 51 ± 19% reduction in enamel mineral loss caused by frequent sugar-solution exposure. The CPP-ACP solutions have also been shown to significantly remineralize enamel subsurface lesions in vitro where a 1.0% w/v CPP-ACP solution replaced 64 ± 20% of mineral lost. CPP-ACP in sugar-free chewing gum has been shown to significantly remineralize enamel subsurface lesions in situ.
These interests encompass:
- Enamel remineralization
- Prevention of dental caries
- CPP-ACP and CPP-ACFP
- Enamel hypomineralisation
- Erosion study
CURRENT RESEARCH PROJECTS
- To inhibit enamel demineralization and promote enamel reminerlization by casein phosphopeptide amorphous calcium phosphate (CPP-ACP)
- To inhibit enamel demineralization and promote enamel reminerlization by casein phosphopeptide amorphous calcium phosphate and fluoride (CPP-ACFP)
- The use of fluoride for the prevention of dental caries
- Prevention of erosion
See Dr. Shen's Find an Expert page at The University of Melbourne.
- International Association of Dental Research