Characterisation of biomineralising peptides and proteins

  • Head of Laboratory Professor Eric Reynolds

    View researcher's webpage

    03 9341 1547

  • Project Details

    Casein phosphopeptides (CPP) stabilise amorphous calcium phosphate as (CPP-ACP) and have been demonstrated to be anticariogenic in our laboratory. The CPP-ACP substantially increase the levels of calcium and phosphate in dental plaque thereby depressing enamel demineralisation and facilitating remineralisation. The motif responsible for stabilisation of amorphous calcium phosphate has been identified using synthetic phosphopeptides as -Ser(P)-Ser(P)-Ser(P)-Glu-Glu-. This technology has been patented and developed commercially by industry partners. It is now commercially available world-wide in sugar-free gum (Recaldent and Xtracare) and in professional oral care products (Tooth Mousse and MI paste). The three dimensional structure of the CPP are currently under investigation using 2-D NMR and computerised molecular modelling. Further proteins involved in biomineralisation and the development of biomimetics are also under investigation.

    Research Group

    Oral Biology Research Group

    Faculty Research Themes

    Infection and Immunology

    School Research Themes

    Oral Infection and Immunity

    Key Contact

    For further information about this research, please contact the research group leader.

    Department / Centre

    Melbourne Dental School

    Unit / Centre

    Oral Biology Research Group

    MDHS Research library
    Explore by researcher, school, project or topic.