Characterisation of novel P. gingivalis cell surface proteinase/adhesins

  • Professor Eric Reynolds

    e.reynolds@unimelb.edu.au

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    03 9341 1547

  • Project Details

    We have a strategic research program to characterize the novel extracellular proteinase/adhesin complexes of P. gingivalis and determine their role in pathogenesis using animal models. Using a combination of genetic and protein approaches including insertional gene inactivation, site-directed mutagenesis, protein cross-linking and mass spectrometric analyses we are determining the structure, function and secretion of these unique cell surface proteins. Using a series of isogenic mutants we have already determined that these proteins are the major virulence factors of the bacterium.

    Research Group

    Oral Biology Research Group



    Faculty Research Themes

    Infection and Immunology

    School Research Themes

    Oral Infection and Immunity



    Key Contact

    For further information about this research, please contact the research group leader.

    Department / Centre

    Melbourne Dental School

    Unit / Centre

    Oral Biology Research Group


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