Characterisation of novel P. gingivalis cell surface proteinase/adhesins
-
Professor Eric Reynolds03 9341 1547
Project Details
We have a strategic research program to characterize the novel extracellular proteinase/adhesin complexes of P. gingivalis and determine their role in pathogenesis using animal models. Using a combination of genetic and protein approaches including insertional gene inactivation, site-directed mutagenesis, protein cross-linking and mass spectrometric analyses we are determining the structure, function and secretion of these unique cell surface proteins. Using a series of isogenic mutants we have already determined that these proteins are the major virulence factors of the bacterium.
Research Group
The Oral Microbiology and Microbiome Group
Faculty Research Themes
School Research Themes
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
Explore by researcher, school, project or topic.